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Studies have shown that asymptomatic individuals with hyperuricemic already exhibit subclinical inflammation (e.g., elevated IL-6 and CRP), whereas acute gout flares are characterized by significant increases in IL-1 and S100A8/A9 levels, which may serve as distinguishing biomarkers (Wu and You, 2023)

Similarly, increased export of GSSG also occurred, potentially contributing to lower intracellular levels

Reporting helps the MHRA identify safety signals even for products outside the standard licensing framework

Regulatory and commercial factors rather than safety concerns explain this limitation

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